Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment
Joint Authors
Drewes, Asbjørn M.
Meldgaard, Theresa
Olesen, Søren Schou
Farmer, Adam D.
Wendel, Anne Astrid
Brock, Birgitte
Krogh, Klaus
Brock, Christina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence.
Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons.
Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy.
The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a “molecule to mechanism” approach to treatment, which will include 4 distinct aspects.
Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures.
Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy.
Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available.
Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.
American Psychological Association (APA)
Meldgaard, Theresa& Olesen, Søren Schou& Farmer, Adam D.& Krogh, Klaus& Wendel, Anne Astrid& Brock, Birgitte…[et al.]. 2018. Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183488
Modern Language Association (MLA)
Meldgaard, Theresa…[et al.]. Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment. Journal of Diabetes Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1183488
American Medical Association (AMA)
Meldgaard, Theresa& Olesen, Søren Schou& Farmer, Adam D.& Krogh, Klaus& Wendel, Anne Astrid& Brock, Birgitte…[et al.]. Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183488