Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus
Joint Authors
Petrovski, Goran
Moe, Morten C.
Dahl-Jørgensen, Knut
Brunborg, Cathrine
Margeirsdottir, Hanna D.
Heier, Martin
Veiby, Nina C. B. B.
Simeunovic, Aida
Saddique, Naila
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background/Objective.
Optical coherence tomography angiography (OCTA) is increasingly used to supplement ophthalmoscopy in the diagnosis and follow-up of diabetic retinopathy.
Our objective was to confirm if OCTA parameters can predict the development of nonproliferative diabetic retinopathy (NPDR) and to clarify if any single OCTA parameter is associated with NPDR independently of well-known risk factors in young type 1 diabetes (T1D) patients.
Methods.
OCTA of both eyes was performed in a cross-sectional study of 14 to 30-year-old individuals with at least 10-year duration of T1D and controls recruited from the Norwegian Atherosclerosis and Childhood Diabetes (ACD) study.
Vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep capillary plexus (SCP and DCP), total retinal volume (TRV), and central macular thickness (CMT) were calculated using automated software.
Univariate and multivariate ordered logistic regression (OLR) models were used accordingly.
Results.
We included 168 control eyes and 315 T1D eyes.
Lower VD in DCP (OR 0.65, 95% CI 0.51–0.83), longer diabetes duration (OR 1.51, 95% CI 1.22–1.87), and higher waist circumference (OR 1.08, 95% CI 1.02–1.14) were significantly associated with progression of NPDR.
VD in SCP and DCP were significantly lower in T1D patients without diabetic retinopathy than in controls.
Conclusions.
Sparser VD in DCP is significantly associated with severity of NPDR, supporting that OCTA might detect the earliest signs of NPDR before it is visible by ophthalmoscopy.
American Psychological Association (APA)
Veiby, Nina C. B. B.& Simeunovic, Aida& Heier, Martin& Brunborg, Cathrine& Saddique, Naila& Moe, Morten C.…[et al.]. 2020. Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183491
Modern Language Association (MLA)
Veiby, Nina C. B. B.…[et al.]. Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus. Journal of Diabetes Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1183491
American Medical Association (AMA)
Veiby, Nina C. B. B.& Simeunovic, Aida& Heier, Martin& Brunborg, Cathrine& Saddique, Naila& Moe, Morten C.…[et al.]. Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183491