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Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability
Joint Authors
Ahmad, Waqar
Shafique, Muhammad
Khan, Mir Azam
Khan, Waheed S.
Maqsood-ur-Rehman, Waheed S.
Khan, Shahzeb
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Famotidine as H2 receptor has antagonistic effects on gastric secretion.
Unfortunately, its hydrophobic nature contributes to its variable and poor oral bioavailability.
In the current study efforts are being made to fabricate famotidine loaded solid lipid nanoparticles with narrow size distribution.
Prepared nanoformulations were pharmaceutically evaluated to confirm the desired boosted oral bioavailability.
Famotidine loaded nanoformulation (FFSe-4) showed particle size 111.9±1.3 nm, polydispersity index 0.464±0.03, zeta potential −33.46±2 mV, entrapment efficiency 84±2.7%, and drug loading capacity 2.709±0.13%.
Drug-excipients compatibility was confirmed by Fourier transformed infrared spectroscopy.
Scanning electron microscopy confirmed spherical shaped, nanosized particles.
Differential scanning calorimetry and powder X-ray diffractometry confirmed the change in crystalline nature.
Prepared nanoformulation was more stable at refrigerated temperature.
In vitro study showed that drug release time is proportional to drug pay load and followed zero order kinetics.
Release exponent (n>0.5) confirmed non-Fickian-diffusion mechanism for drug release.
In vivo pharmacokinetic studies showed 2.06-fold increase in oral bioavailability of famotidine dispersed in solid lipid nanoparticles compared to commercial product.
These results authenticate solid lipid nanoparticles as drug delivery system and propose prolonged release with improved oral bioavailability for famotidine.
American Psychological Association (APA)
Shafique, Muhammad& Khan, Mir Azam& Khan, Waheed S.& Maqsood-ur-Rehman, Waheed S.& Ahmad, Waqar& Khan, Shahzeb. 2017. Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1183531
Modern Language Association (MLA)
Shafique, Muhammad…[et al.]. Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability. Journal of Nanomaterials No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1183531
American Medical Association (AMA)
Shafique, Muhammad& Khan, Mir Azam& Khan, Waheed S.& Maqsood-ur-Rehman, Waheed S.& Ahmad, Waqar& Khan, Shahzeb. Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1183531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183531