Neonatal Hypoglycemia Related to Glycine Levels in Uncontrolled Gestational Diabetes Mellitus during Mid-Late Pregnancy: Multicenter, Prospective Case-Cohort Observational Study
Joint Authors
Cao, Jianyong
Bao, Xin
Xie, Dan
Wang, Jianying
Chen, Le
Chen, Yao
Long, Yuhang
Yang, Yaochao
Zhang, Hanxi
Liu, Meijun
Chen, WuJuan
Jiang, Fangfang
Hong, Ting
Su, Zhaojuan
Liu, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aims.
To explore the relationship between gestational diabetes mellitus (GDM) and neonatal cord blood amino acid and carnitine levels after GDM was diagnosed among pregnant women monitoring glycosylated haemoglobin levels of 5.5%-6.4% during mid-late gestation.
Methods.
In all, 7289 qualified participants were recruited and divided into two groups (GDM and control groups) between 1 July 2015 and 1 July 2020, and all maternal-neonatal data were collected and analyzed at three centers.
Results.
Interestingly, glycine in cord blood was not only significantly different between groups (15.52 vs.
6.67, P<0.001) but also associated with neonatal hypoglycemia (r=0.132, P<0.001).
Although glycine was an independent positive factor with neonatal hypoglycemia, it had lacked effective size to predict the risk of neonatal hypoglycemia (b=0.002, P<0.001).
Conclusion.
The study identifies some differences and relationships in maternal-neonatal data when the GDM group has fluctuating glycosylated haemoglobin levels of 5.5%-6.4% without hypoglycemic drug intervention, compared with the control group.
Although umbilical cord blood of glycine levels has a lack of effective power to predict the risk of neonatal hypoglycemia, it is probably an independent factor involved in the maternal-neonatal glucolipid metabolism.
American Psychological Association (APA)
Long, Yuhang& Chen, Le& Yang, Yaochao& Liu, Wei& Zhang, Hanxi& Bao, Xin…[et al.]. 2020. Neonatal Hypoglycemia Related to Glycine Levels in Uncontrolled Gestational Diabetes Mellitus during Mid-Late Pregnancy: Multicenter, Prospective Case-Cohort Observational Study. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183571
Modern Language Association (MLA)
Long, Yuhang…[et al.]. Neonatal Hypoglycemia Related to Glycine Levels in Uncontrolled Gestational Diabetes Mellitus during Mid-Late Pregnancy: Multicenter, Prospective Case-Cohort Observational Study. Journal of Diabetes Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1183571
American Medical Association (AMA)
Long, Yuhang& Chen, Le& Yang, Yaochao& Liu, Wei& Zhang, Hanxi& Bao, Xin…[et al.]. Neonatal Hypoglycemia Related to Glycine Levels in Uncontrolled Gestational Diabetes Mellitus during Mid-Late Pregnancy: Multicenter, Prospective Case-Cohort Observational Study. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183571