![](/images/graphics-bg.png)
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
Joint Authors
Slaby, Ondrej
Hubálek, Jaromír
Kovář, David
Malá, Aneta
Mlčochová, Jitka
Kalina, Michal
Fohlerová, Zdenka
Hlaváček, Antonín
Farka, Zdeněk
Skládal, Petr
Starčuk, Zenon
Jiřík, Radovan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution.
Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years.
Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging.
Furthermore, their unique small size also allows them to migrate into cells and other body compartments.
To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times.
The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability.
The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity.
Biocompatibility was tested on the Caki-2 cells with good tolerance.
The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated.
The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.
American Psychological Association (APA)
Kovář, David& Malá, Aneta& Mlčochová, Jitka& Kalina, Michal& Fohlerová, Zdenka& Hlaváček, Antonín…[et al.]. 2017. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1183600
Modern Language Association (MLA)
Kovář, David…[et al.]. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. Journal of Nanomaterials No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1183600
American Medical Association (AMA)
Kovář, David& Malá, Aneta& Mlčochová, Jitka& Kalina, Michal& Fohlerová, Zdenka& Hlaváček, Antonín…[et al.]. Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1183600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183600