MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy
Joint Authors
Zhang, Yingying
Zhao, Siqi
Wu, Depei
Liu, Xingmei
Shi, Mingjun
Wang, Yuanyuan
Zhang, Fan
Ding, Jing
Xiao, Ying
Guo, Bing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Renal tubulointerstitial fibrosis (TIF) is a major feature of diabetic nephropathy (DN).
There is increasing evidence demonstrating that microRNAs act as key players in the regulation of autophagy and are involved in DN.
However, the exact link among microRNAs, autophagy, and TIF in DN is largely unknown.
In this study, our results showed that TIF was observed in DN rats together with obvious autophagy suppression.
Moreover, microRNA-22 (miR-22) was upregulated and associated with reduced expression of its target gene phosphatase and tensin homolog (PTEN) in both the kidneys of DN rats and high glucose-cultured NRK-52E cells.
Intriguingly, induction of autophagy by rapamycin antagonized high glucose-induced collagen IV (Col IV) and α-SMA expression.
In addition, ectopic expression of miR-22 suppressed autophagic flux and induced the expression of Col IV and α-SMA, whereas the inhibition of endogenous miR-22 effectively relieved high glucose-induced autophagy suppression and the expression of Col IV and α-SMA in NRK-52E cells.
Overexpression of PTEN protectively antagonized high glucose- and miR-22-induced autophagy suppression and the expression of Col IV.
Therefore, our findings indicated that miR-22 may promote TIF by suppressing autophagy partially via targeting PTEN and represents a novel and promising therapeutic target for DN.
American Psychological Association (APA)
Zhang, Yingying& Zhao, Siqi& Wu, Depei& Liu, Xingmei& Shi, Mingjun& Wang, Yuanyuan…[et al.]. 2018. MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183603
Modern Language Association (MLA)
Zhang, Yingying…[et al.]. MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1183603
American Medical Association (AMA)
Zhang, Yingying& Zhao, Siqi& Wu, Depei& Liu, Xingmei& Shi, Mingjun& Wang, Yuanyuan…[et al.]. MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183603