The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana
Joint Authors
Kantanka, Osei Sarfo
Sarfo, Fred S.
Ansah, Eunice Oparebea
Kyei, Ishmael
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites.
The effect is yet to be studied among African populations.
Methods.
This is a cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic in Kumasi, Ghana.
CHD risk was estimated using the Framingham and UKPDS risk scores.
Risks were categorised as low (<10%), intermediate (10–19%), and high (≥20%).
Associations between metabolic risk factors, thyroid dysfunction, and CHD risk were measured using Spearman’s partial correlation analysis while controlling for age and gender.
Differences were considered statistically significant at p<0.05.
Results.
780 T2DM patients (57.7% females), mean ± SD age of 57.4 ± 9.4 was analysed.
The median (IQR) 10-year CHD score estimated using the Framingham and UKPDS risk engines for males and females was 12 (8–20), 9.4 (5.7–13.4), p<0.0001 and 3 (1–6), 5.8 (3.4–9.6), p<0.0001, respectively.
Positive correlation was found between CHD risk and HbA1c, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, and thyroid stimulating hormone.
Conclusion.
The presence of thyroid dysfunction significantly increased the CHD risk associated with T2DM patients in Ghana.
American Psychological Association (APA)
Kantanka, Osei Sarfo& Sarfo, Fred S.& Ansah, Eunice Oparebea& Kyei, Ishmael. 2018. The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183613
Modern Language Association (MLA)
Kantanka, Osei Sarfo…[et al.]. The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183613
American Medical Association (AMA)
Kantanka, Osei Sarfo& Sarfo, Fred S.& Ansah, Eunice Oparebea& Kyei, Ishmael. The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183613