Glomerular Filtration Rate andor Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study
Joint Authors
Valls, Aida
Moreno, Antonio
Romero-Aroca, Pedro
Baget-Bernaldiz, Marc
Navarro-Gil, Raul
Barrot, Joan
Sagarra-Alamo, Ramon
Mundet-Tuduri, Xavier
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients.
Methods.
A prospective ten-year follow-up population-based study.
We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio.
Results.
Annual incidence of any-DR was 8.21 ± 0.60% (7.06%–8.92%), sight-threatening diabetic retinopathy (STDR) was 2.65 ± 0.14% (2.48%–2.88%), and diabetic macular edema (DME) was 2.21 ± 0.18% (2%–2.49%).
Renal study results were as follows: UACR > 30 mg/g had an annual incidence of 7.02 ± 0.05% (6.97%–7.09%), eGFR < 60 ml/min/1.73 m2 incidence was 5.89 ± 0.12% (5.70%–6.13%).
Cox’s proportional regression analysis of DR incidence shows that renal function studied by eGFR < 60 ml/min/1.73 m2 was less significant (p=0.04, HR 1.223, 1.098–1.201) than UACR ≥ 300 mg/g (p<0.001, HR 1.485, 1.103–1.548).
The study of STDR shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.890, 1.267–2.820), UACR ≥ 300 mg/g (p<0.001, HR 2.448, 1.595–3.757), and DME shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.920, 1.287–2.864) and UACR ≥ 300 mg/g (p<0.001, HR 2.432, 1.584–3.732).
Conclusions.
The UACR has a better association with diabetic retinopathy than the eGFR, although both are important risk factors for diabetic retinopathy.
American Psychological Association (APA)
Romero-Aroca, Pedro& Baget-Bernaldiz, Marc& Navarro-Gil, Raul& Moreno, Antonio& Valls, Aida& Sagarra-Alamo, Ramon…[et al.]. 2018. Glomerular Filtration Rate andor Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183689
Modern Language Association (MLA)
Romero-Aroca, Pedro…[et al.]. Glomerular Filtration Rate andor Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183689
American Medical Association (AMA)
Romero-Aroca, Pedro& Baget-Bernaldiz, Marc& Navarro-Gil, Raul& Moreno, Antonio& Valls, Aida& Sagarra-Alamo, Ramon…[et al.]. Glomerular Filtration Rate andor Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183689