Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot
Joint Authors
Jansen, Rasmus Bo
Svendsen, Ole Lander
Christensen, Tomas Møller
Bülow, Jens
Rørdam, Lene
Jørgensen, Niklas Rye
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure.
The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements.
Methods.
We included patients with acute diabetic Charcot foot.
Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis.
To minimize the A-V shunting effect, the feet were externally cooled with ice water prior to resampling.
Results.
Both before and after cooling, the A-V flux of interleukin-6 (IL-6) between the Charcot feet and the arterial level was significantly higher than the flux between the healthy feet and the arterial level (Δvaluebefore: 7.25 versus 0.41 pg/mL, resp., p=0.008; Δvalueafter: 10.04 versus 1.68 pg/mL, resp., p=0.032).
There were no differences in the fluxes for other markers of inflammation.
Conclusion.
We have found an increased A-V flux of IL-6 in the acute diabetic Charcot foot compared to the healthy foot in the same patients.
American Psychological Association (APA)
Jansen, Rasmus Bo& Christensen, Tomas Møller& Bülow, Jens& Rørdam, Lene& Jørgensen, Niklas Rye& Svendsen, Ole Lander. 2018. Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183692
Modern Language Association (MLA)
Jansen, Rasmus Bo…[et al.]. Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183692
American Medical Association (AMA)
Jansen, Rasmus Bo& Christensen, Tomas Møller& Bülow, Jens& Rørdam, Lene& Jørgensen, Niklas Rye& Svendsen, Ole Lander. Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183692