Formation and Investigation of Electrospun PLA Materials with Propolis Extracts and Silver Nanoparticles for Biomedical Applications
Joint Authors
Briedis, Vitalis
Juškaitė, Vaida
Adomavičiūtė, Erika
Stanys, Sigitas
Pavilonis, Alvydas
Pupkevičiūtė, Solveiga
Žilius, Modestas
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
An electrospun hydrophilic non-water-soluble biocompatible polylactic acid (PLA) nonwoven material was used as a delivery system for propolis ethanolic extract (PEE) and silver nanoparticles (AgNPs) that are known for their established antiseptic and antimicrobial activity.
Combination of PEE and AgNPs in a single product should provide efficient antimicrobial protection and improved wound healing.
Evaluations of PEE and AgNPs on morphology of electrospun materials, release kinetics of AgNPs and phenolic compounds, antibacterial properties, and cytotoxicity of electrospun PLA materials were performed.
The presence of PEE or/and AgNPs resulted in denser mats formed by thicker PLA fibers.
The average diameter of PLA microfibers was 168±29 nm.
The average diameter of microfibers increased to 318±40 and 370±30 nm when 10 wt% and 20 wt% ethanol were added, respectively.
Addition of 10 wt% or 20 wt% PEE increased the diameter to 282±25 and 371±25 nm, respectively.
Suspension of AgNPs also caused the formation of thicker microfibers with 254±25 nm diameter.
Electrospun PLA microfibers with PEE maintained viability of HaCaT cells.
Testing of antimicrobial activity confirmed the ability of AgNPs containing PLA electrospun materials to inhibit the growth of microorganisms.
American Psychological Association (APA)
Adomavičiūtė, Erika& Pupkevičiūtė, Solveiga& Juškaitė, Vaida& Žilius, Modestas& Stanys, Sigitas& Pavilonis, Alvydas…[et al.]. 2017. Formation and Investigation of Electrospun PLA Materials with Propolis Extracts and Silver Nanoparticles for Biomedical Applications. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183717
Modern Language Association (MLA)
Adomavičiūtė, Erika…[et al.]. Formation and Investigation of Electrospun PLA Materials with Propolis Extracts and Silver Nanoparticles for Biomedical Applications. Journal of Nanomaterials No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1183717
American Medical Association (AMA)
Adomavičiūtė, Erika& Pupkevičiūtė, Solveiga& Juškaitė, Vaida& Žilius, Modestas& Stanys, Sigitas& Pavilonis, Alvydas…[et al.]. Formation and Investigation of Electrospun PLA Materials with Propolis Extracts and Silver Nanoparticles for Biomedical Applications. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183717