Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles
Joint Authors
Cárdenas-Triviño, Galo
Ruiz-Parra, Macarena
Vergara-González, Luis
Ojeda-Oyarzún, Javier
Solorzano, Guillermo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A study on the nanoparticles size and the antibacterial properties of hyaluronic acid (HA) doped with nanoparticles is reported.
Nanoparticles from gold, silver, copper, and silver palladium with HA support were performed.
The solvated metal atom dispersion (SMAD) method with 2-propanol and HA was used.
High-resolution transmission electron microscopy (HRTEM), infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA) were conducted.
The average sizes of nanoclusters were as follows: HA-Au = 17.88 nm; HA-Ag = 50.41 nm; HA-Cu = 13.33 nm; and HA-AgPd = 33.22 nm.
The antibacterial activity of solutions and films containing nanoparticles against American Type Culture Collection (ATCC) bacterial strains Escherichia coli (EC), Staphylococcus aureus (SA), Staphylococcus epidermidis (SE), and Pseudomonas aeruginosa (PA) was determined.
Inhibition was observed for HA-Ag, HA-Cu, and HA-AgPd.
Toxicological tests were performed in rats that were injected intraperitoneally with two concentrations of gold, copper, silver, and silver-palladium nanoparticles.
No alterations in hepatic parameters, including ALT (alanine aminotransferase), GGT (gamma-glutamyl transpeptidase) bilirubin, and albumin, were observed after 14 days.
These films could be used as promoters of skin recovery and Grades I and II cutaneous burns and as scaffolds.
American Psychological Association (APA)
Cárdenas-Triviño, Galo& Ruiz-Parra, Macarena& Vergara-González, Luis& Ojeda-Oyarzún, Javier& Solorzano, Guillermo. 2017. Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183843
Modern Language Association (MLA)
Cárdenas-Triviño, Galo…[et al.]. Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles. Journal of Nanomaterials No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1183843
American Medical Association (AMA)
Cárdenas-Triviño, Galo& Ruiz-Parra, Macarena& Vergara-González, Luis& Ojeda-Oyarzún, Javier& Solorzano, Guillermo. Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183843