Enhanced Radiosensitization Effect of Curcumin Delivered by PVP-PCL Nanoparticle in Lung Cancer
Joint Authors
Yin, Haitao
Wen, Cuixia
Zhou, Yun
Zhou, Chong
Zhang, Yifan
Hu, Xiang
Li, Jun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Curcumin, the principal polyphenolic curcuminoid, has been reported in numerous studies for its antitumor effect in a series of cancers.
It is also reported that curcumin possesses radiosensitization effect in some cancers.
However, the poor solubility and unsatisfied bioavailability of curcumin significantly undermine its potential application.
Here we prepared curcumin loaded nanoparticles by employing PVP-PCL as drug carrier.
Characterization studies indicated the satisfied drug loading efficiency and a sustained in vitro release pattern.
Quantification uptake study showed that the uptake efficiency of Cum-NPs by lung cancer cells was time- and dose-dependent.
In vitro anticancer study demonstrated the superior cytotoxic effect of Cum-NPs with stronger apoptotic induction over free Cum.
Most importantly, there is almost no report on the radiosensitization effect of curcumin loaded nanoparticles.
Here, Cum-NPs led to more inhibition of the colony forming ability of A549 cells as compared to the equivalent concentration of free Cum as shown in clonogenic assay.
Furthermore, Cum-NPs are much more effective in enhancing the tumor growth inhibitory effect of radiation therapy in a A549 xenograft model.
Therefore, results from the current study seem to be the first report on the radiosensitization effect of Cum-NPs and paved the way for a curcumin nanodrug delivery system as a potential radiation adjuvant.
American Psychological Association (APA)
Wen, Cuixia& Zhou, Yun& Zhou, Chong& Zhang, Yifan& Hu, Xiang& Li, Jun…[et al.]. 2017. Enhanced Radiosensitization Effect of Curcumin Delivered by PVP-PCL Nanoparticle in Lung Cancer. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1183851
Modern Language Association (MLA)
Wen, Cuixia…[et al.]. Enhanced Radiosensitization Effect of Curcumin Delivered by PVP-PCL Nanoparticle in Lung Cancer. Journal of Nanomaterials No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1183851
American Medical Association (AMA)
Wen, Cuixia& Zhou, Yun& Zhou, Chong& Zhang, Yifan& Hu, Xiang& Li, Jun…[et al.]. Enhanced Radiosensitization Effect of Curcumin Delivered by PVP-PCL Nanoparticle in Lung Cancer. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1183851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183851