Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics
Joint Authors
Berger, Daniela
Mitran, Raul-Augustin
Pandele-Cusu, Jeanina
Matei, Cristian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mesoporous silica materials are promising nanocarriers for the development of drug delivery systems.
In this study, the influence of pore size, volume, surface area, and doping the silica framework on the release kinetics of a model drug, metoprolol, has been studied.
20% or 50% wt.
therapeutic agent was loaded into the carrier mesopores through incipient wetness impregnation.
The carriers and drug-loaded samples have been characterized by small- and wide-angle X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms.
The in vitro release profiles have been fitted using a three-parameter kinetic model and they have been explained in terms of the release rate during the burst and sustained release stages and the fraction of drug molecules released during the burst stage.
The silica framework doping with aluminum was found to decrease the amount of drug released in the burst stage, without affecting the other kinetic parameters.
The therapeutic agent release rates depend mainly on the pore size and volume of the mesoporous carriers and drug-loaded samples.
American Psychological Association (APA)
Mitran, Raul-Augustin& Berger, Daniela& Pandele-Cusu, Jeanina& Matei, Cristian. 2017. Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183881
Modern Language Association (MLA)
Mitran, Raul-Augustin…[et al.]. Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics. Journal of Nanomaterials No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1183881
American Medical Association (AMA)
Mitran, Raul-Augustin& Berger, Daniela& Pandele-Cusu, Jeanina& Matei, Cristian. Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183881