TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes
Joint Authors
Yang, Gangyi
Leng, Weiling
Lei, Xiaotian
Liang, Ziwen
QiNan, Wu
XiaGuang, Gan
Ling, Zhang
Chen, Liu
MengLiu, Yang
Bing, Chen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Islet β cell apoptosis plays an important role in type 2 diabetes.
We previously reported that Par-4-mediated islet β cell apoptosis is induced by high-glucose/fatty acid levels.
In the present study, we show that Par-4, which is induced by high-glucose/fatty acid levels, interacts with and inhibits TERT in the cytoplasm and then translocates to the nucleus.
Par-4 also inhibited Akt phosphorylation, leading to islet β cell apoptosis.
We inhibited Par-4 in islet β cells under high-glucose/fatty acid conditions and knocked out Par-4 in diabetic mice, which led to the up-regulation of TERT and an improvement in the apoptosis rate.
We inhibited Akt phosphorylation in islet β cells and diabetic mice, which led to aggressive apoptosis.
In addition, the biological film interference technique revealed that Par-4 bound to TERT via its NLS and leucine zipper domains.
Our research suggests that Par-4 activation and binding to TERT are key steps required for inducing the apoptosis of islet β cells under high-glucose/fatty acid conditions.
Inhibiting Akt phosphorylation aggravated apoptosis by activating Par-4 and inhibiting TERT, and Par-4 inhibition may be an attractive target for the treatment of islet β cell apoptosis.
American Psychological Association (APA)
Chen, Liu& QiNan, Wu& Lei, Xiaotian& MengLiu, Yang& XiaGuang, Gan& Leng, Weiling…[et al.]. 2018. TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1183888
Modern Language Association (MLA)
Chen, Liu…[et al.]. TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes. Journal of Diabetes Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1183888
American Medical Association (AMA)
Chen, Liu& QiNan, Wu& Lei, Xiaotian& MengLiu, Yang& XiaGuang, Gan& Leng, Weiling…[et al.]. TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1183888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183888