Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence
Joint Authors
Kielstein, Heike
Bähr, Ina
Goritz, Vincent
Doberstein, Henriette
Hiller, Grit Gesine Ruth
Rosenstock, Philip
Jahn, Janine
Pörtner, Ole
Berreis, Tobias
Mueller, Thomas
Spielmann, Julia
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Obesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear.
Previous studies showed altered Natural killer (NK) cell functions in obese individuals.
Therefore, we studied the impact of an impaired NK cell functionality on the increased colon cancer risk in obesity.
In vitro investigations demonstrated a decreased IFN-γ secretion and cytotoxicity of human NK cells against colon tumor cells after NK cell preincubation with the adipokine leptin.
In addition, leptin incubation decreased the expression of activating NK cell receptors.
In animal studies, colon cancer growth was induced by injection of azoxymethane (AOM) in normal weight and diet-induced obese rats.
Body weight and visceral fat mass were increased in obese animals compared to normal weight rats.
AOM-treated obese rats showed an increased quantity, size, and weight of colon tumors compared to the normal weight tumor group.
Immunohistochemical analyses demonstrated a decreased number of NK cells in spleen and liver in obesity.
Additionally, the expression levels of activating NK cell receptors were lower in spleen and liver of obese rats.
The results show for the first time that the decreased number and impaired NK cell function may be one cause for the higher colon cancer risk in obesity.
American Psychological Association (APA)
Bähr, Ina& Goritz, Vincent& Doberstein, Henriette& Hiller, Grit Gesine Ruth& Rosenstock, Philip& Jahn, Janine…[et al.]. 2017. Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence. Journal of Nutrition and Metabolism،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1183941
Modern Language Association (MLA)
Bähr, Ina…[et al.]. Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence. Journal of Nutrition and Metabolism No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1183941
American Medical Association (AMA)
Bähr, Ina& Goritz, Vincent& Doberstein, Henriette& Hiller, Grit Gesine Ruth& Rosenstock, Philip& Jahn, Janine…[et al.]. Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence. Journal of Nutrition and Metabolism. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1183941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183941