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Rationales for the Use of Cancer Stem Cells Markers in the Staging of Papillary Thyroid Carcinoma
Joint Authors
Mahmood, Noah Abd-Alkader
Tawfeeq, Amer Talib
Al-Sudani, Israa Mhdi
Abd-Alghni, Zaynab Saad
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fine needle aspiration biopsy (FNAB) is a standard procedure for the detection of thyroid nodules malignancy, yet 10-25% of the sample diagnosed may go undetermined or suspicious.
The utility of cancer stem cell markers (CSCM) as a differential diagnosis molecular marker in nodules of suspicious decision in FNAB was hypothesized.
Papillary thyroid carcinoma (PTC) and thyroid fibroadenoma (TFA) samples were selected to test the hypothesis.
The samples employed in this study were from patients who had thyroid hyperplasia and a suspicious or undetermined diagnosis by FNAB.
The patient underwent a successful thyroidectomy at Al-Yarmouk Teaching Hospital in Baghdad between January 2015 and December 2017.
All nodule samples underwent a systematic histopathological examination after resection.
Tumors diagnosed as PTC and those diagnosed as fibroadenoma (TFA) were selected for this study.
Collectively 39 PTC and 11 TFA nodules were included.
Quantitative reverse transcriptase real-time PCR (qRT-PCR) and immunohistochemistry (IHC) were used to determine levels of mRNA and proteins of CSCM ALDH1A1, CD44, ABCG2, and Oct3/4 in both types of tumors were used.
This study revealed that the expression levels of CSCM were significantly increased in PTC tissues when compared to benign tissues and the positive correlation was found between the CSCM expression levels and tumor stage, size, and gender.
In conclusion, for a more precise diagnosis, we suggest these markers be included in what is currently available to characterize malignancy from what is not in thyroid cancer, as well as for the staging process of PTC.
American Psychological Association (APA)
Mahmood, Noah Abd-Alkader& Tawfeeq, Amer Talib& Al-Sudani, Israa Mhdi& Abd-Alghni, Zaynab Saad. 2019. Rationales for the Use of Cancer Stem Cells Markers in the Staging of Papillary Thyroid Carcinoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1183948
Modern Language Association (MLA)
Mahmood, Noah Abd-Alkader…[et al.]. Rationales for the Use of Cancer Stem Cells Markers in the Staging of Papillary Thyroid Carcinoma. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1183948
American Medical Association (AMA)
Mahmood, Noah Abd-Alkader& Tawfeeq, Amer Talib& Al-Sudani, Israa Mhdi& Abd-Alghni, Zaynab Saad. Rationales for the Use of Cancer Stem Cells Markers in the Staging of Papillary Thyroid Carcinoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1183948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183948