Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes
Joint Authors
Feng, Cindy
Osgood, Nathaniel D.
Dyck, Roland F.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Obesity history may provide a better understanding of the contribution of obesity to T2DM risk.
Methods.
17,634 participants from the 1958 National Child Development Study were followed from birth to 50 years.
Cumulative obesity dose, a measure of obesity history, was calculated by subtracting the upper cut-off of the normal BMI from the actual BMI at each follow-up and summing the areas under the obesity dose curve.
Hazard ratios (HRs) for diabetes were calculated using Cox regression analysis.
Three separate models compared the predictive ability of cumulative obesity dose on diabetes risk with the time-varying BMI and last BMI.
Results.
In final models, 341 of 15,043 (2.27%) participants developed diabetes; male sex and low birth weight were significant confounding variables.
Adjusted HRs were 1.080 (95% CI: 1.071, 1.088) per 10-unit cumulative obesity dose, 1.098 (95% CI: 1.080, 1.117) per unit of the time-varying BMI, and 1.146 (95% CI: 1.084, 1.212) per unit of the last BMI.
Cumulative obesity dose provided the best predictive ability for diabetes.
Conclusions.
Cumulative obesity dose is an improved method for evaluating the impact of obesity history on diabetes risk.
The link between low birth weight and T2DM is strengthened by adjusting for cumulative obesity dose.
American Psychological Association (APA)
Feng, Cindy& Osgood, Nathaniel D.& Dyck, Roland F.. 2018. Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183955
Modern Language Association (MLA)
Feng, Cindy…[et al.]. Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183955
American Medical Association (AMA)
Feng, Cindy& Osgood, Nathaniel D.& Dyck, Roland F.. Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183955