![](/images/graphics-bg.png)
Molecular and Clinical Insights into the Invasive Capacity of Glioblastoma Cells
Joint Authors
Velásquez, Carlos
Mora, Carla
Nassiri, Farshad
Suppiah, Suganth
Martino, Juan
Fernández-Luna, José L.
Zadeh, Gelareh
Mansouri, Sheila
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-29
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The invasive capacity of GBM is one of the key tumoral features associated with treatment resistance, recurrence, and poor overall survival.
The molecular machinery underlying GBM invasiveness comprises an intricate network of signaling pathways and interactions with the extracellular matrix and host cells.
Among them, PI3k/Akt, Wnt, Hedgehog, and NFkB play a crucial role in the cellular processes related to invasion.
A better understanding of these pathways could potentially help in developing new therapeutic approaches with better outcomes.
Nevertheless, despite significant advances made over the last decade on these molecular and cellular mechanisms, they have not been translated into the clinical practice.
Moreover, targeting the infiltrative tumor and its significance regarding outcome is still a major clinical challenge.
For instance, the pre- and intraoperative methods used to identify the infiltrative tumor are limited when trying to accurately define the tumor boundaries and the burden of tumor cells in the infiltrated parenchyma.
Besides, the impact of treating the infiltrative tumor remains unclear.
Here we aim to highlight the molecular and clinical hallmarks of invasion in GBM.
American Psychological Association (APA)
Velásquez, Carlos& Mansouri, Sheila& Mora, Carla& Nassiri, Farshad& Suppiah, Suganth& Martino, Juan…[et al.]. 2019. Molecular and Clinical Insights into the Invasive Capacity of Glioblastoma Cells. Journal of Oncology،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1183959
Modern Language Association (MLA)
Velásquez, Carlos…[et al.]. Molecular and Clinical Insights into the Invasive Capacity of Glioblastoma Cells. Journal of Oncology No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1183959
American Medical Association (AMA)
Velásquez, Carlos& Mansouri, Sheila& Mora, Carla& Nassiri, Farshad& Suppiah, Suganth& Martino, Juan…[et al.]. Molecular and Clinical Insights into the Invasive Capacity of Glioblastoma Cells. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1183959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183959