The SR-B1 Receptor as a Potential Target for Treating Glioblastoma
Joint Authors
Raut, Sangram
Berney, Ethan
Sabnis, Nirupama
Panchoo, Marlyn
Dickerman, Rob
Lacko, Andras G.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
The goal of these studies was to provide proof of concept for a novel targeted therapy for Glioblastoma Multiforme (GBM).
Methods.
These studies involve the evaluation of reconstituted high density lipoprotein (rHDL) nanoparticles (NPs) as delivery agents for the drug, mammalian Target of Rapamycin (mTOR) inhibitor Everolimus (EVR) to GBM cells.
Cytotoxicity studies and assessment of downstream effects, including apoptosis, migration, and cell cycle events, were probed, in relation to the expression of scavenger receptor B type 1 (SR-B1) by GBM cells.
Results.
Findings from cytotoxicity studies indicate that the rHDL/EVR formulation was 185 times more potent than free EVR against high SR-B1 expressing cell line (LN 229).
Cell cycle analysis revealed that rHDL/EVR treated LN229 cells had a 5.8 times higher apoptotic cell population than those treated with EVR.
The sensitivity of GBM cells to EVR treatment was strongly correlated with SR-B1 expression.
Conclusions.
These studies present strong proof of concept regarding the efficacy of delivering EVR and likely other agents, via a biocompatible transport system, targeted to the SR-B1 receptor that is upregulated in most cancers, including GBM.
Targeting the SR-B1 receptor could thus lead to effective personalized therapy of GBM.
American Psychological Association (APA)
Berney, Ethan& Sabnis, Nirupama& Panchoo, Marlyn& Raut, Sangram& Dickerman, Rob& Lacko, Andras G.. 2019. The SR-B1 Receptor as a Potential Target for Treating Glioblastoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1183982
Modern Language Association (MLA)
Berney, Ethan…[et al.]. The SR-B1 Receptor as a Potential Target for Treating Glioblastoma. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1183982
American Medical Association (AMA)
Berney, Ethan& Sabnis, Nirupama& Panchoo, Marlyn& Raut, Sangram& Dickerman, Rob& Lacko, Andras G.. The SR-B1 Receptor as a Potential Target for Treating Glioblastoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1183982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183982