Metabolomic Insights into the Nutritional Status of Adults and Adolescents with Phenylketonuria Consuming a Low-Phenylalanine Diet in Combination with Amino Acid and Glycomacropeptide Medical Foods
Joint Authors
Stroup, Bridget M.
Murali, Sangita G.
Ney, Denise M.
Rohr, Frances
Gleason, Sally T.
van Calcar, Sandra C.
Levy, Harvey L.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
Nutrient status in phenylketonuria (PKU) requires surveillance due to the restrictive low-Phe diet in combination with amino acid medical foods (AA-MF) or glycomacropeptide medical foods (GMP-MF).
Micronutrient profiles of medical foods are diverse, and optimal micronutrient supplementation in PKU has not been established.
Methods.
In a crossover design, 30 participants with PKU were randomized to consume AA-MF and Glytactin™ GMP-MF in combination with a low-Phe diet for 3 weeks each.
Fasting venipunctures, medical food logs, and 3-day food records were obtained.
Metabolomic analyses were completed in plasma and urine by Metabolon, Inc.
Results.
The low-Phe diets in combination with AA-MF and GMP-MF were generally adequate based on Dietary Reference Intakes, clinical measures, and metabolomics.
Without micronutrient supplementation of medical foods, >70% of participants would have inadequate intakes for 11 micronutrients.
Despite micronutrient supplementation of medical foods, inadequate intakes of potassium in 93% of participants and choline in >40% and excessive intakes of sodium in >63% of participants and folic acid in >27% were observed.
Sugar intake was excessive and provided 27% of energy.
Conclusions.
Nutrient status was similar with AA-MF and Glytactin GMP-MF.
More research related to micronutrient supplementation of medical foods for the management of PKU is needed.
American Psychological Association (APA)
Stroup, Bridget M.& Ney, Denise M.& Murali, Sangita G.& Rohr, Frances& Gleason, Sally T.& van Calcar, Sandra C.…[et al.]. 2017. Metabolomic Insights into the Nutritional Status of Adults and Adolescents with Phenylketonuria Consuming a Low-Phenylalanine Diet in Combination with Amino Acid and Glycomacropeptide Medical Foods. Journal of Nutrition and Metabolism،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1183998
Modern Language Association (MLA)
Stroup, Bridget M.…[et al.]. Metabolomic Insights into the Nutritional Status of Adults and Adolescents with Phenylketonuria Consuming a Low-Phenylalanine Diet in Combination with Amino Acid and Glycomacropeptide Medical Foods. Journal of Nutrition and Metabolism No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1183998
American Medical Association (AMA)
Stroup, Bridget M.& Ney, Denise M.& Murali, Sangita G.& Rohr, Frances& Gleason, Sally T.& van Calcar, Sandra C.…[et al.]. Metabolomic Insights into the Nutritional Status of Adults and Adolescents with Phenylketonuria Consuming a Low-Phenylalanine Diet in Combination with Amino Acid and Glycomacropeptide Medical Foods. Journal of Nutrition and Metabolism. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1183998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183998