Targeting L-Lactate Metabolism to Overcome Resistance to Immune Therapy of Melanoma and Other Tumor Entities
Joint Authors
Feichtinger, René G.
Lang, Roland
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although immunotherapy plays a significant role in tumor therapy, its efficacy is impaired by an immunosuppressive tumor microenvironment.
A molecule that contributes to the protumor microenvironment is the metabolic product lactate.
Lactate is produced in large amounts by cancer cells in response to either hypoxia or pseudohypoxia, and its presence in excess alters the normal functioning of immune cells.
A key enzyme involved in lactate metabolism is lactate dehydrogenase (LDH).
Elevated baseline LDH serum levels are associated with poor outcomes of current anticancer (immune) therapies, especially in patients with melanoma.
Therefore, targeting LDH and other molecules involved in lactate metabolism might improve the efficacy of immune therapies.
This review summarizes current knowledge about lactate metabolism and its role in the tumor microenvironment.
Based on that information, we develop a rationale for deploying drugs that target lactate metabolism in combination with immune checkpoint inhibitors to overcome lactate-mediated immune escape of tumor cells.
American Psychological Association (APA)
Feichtinger, René G.& Lang, Roland. 2019. Targeting L-Lactate Metabolism to Overcome Resistance to Immune Therapy of Melanoma and Other Tumor Entities. Journal of Oncology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184006
Modern Language Association (MLA)
Feichtinger, René G.& Lang, Roland. Targeting L-Lactate Metabolism to Overcome Resistance to Immune Therapy of Melanoma and Other Tumor Entities. Journal of Oncology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1184006
American Medical Association (AMA)
Feichtinger, René G.& Lang, Roland. Targeting L-Lactate Metabolism to Overcome Resistance to Immune Therapy of Melanoma and Other Tumor Entities. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184006