The Role of Deubiquitinases in Oncovirus and Host Interactions
Joint Authors
Li, Yueshuo
Shi, Feng
Hu, Jianmin
Xie, Longlong
Bode, Ann M.
Cao, Ya
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Infection-related cancer comprises one-sixth of the global cancer burden.
Oncoviruses can directly or indirectly contribute to tumorigenesis.
Ubiquitination is a dynamic and reversible posttranslational modification that participates in almost all cellular processes.
Hijacking of the ubiquitin system by viruses continues to emerge as a central theme around the viral life cycle.
Deubiquitinating enzymes (DUBs) maintain ubiquitin homeostasis by removing ubiquitin modifications from target proteins, thereby altering protein function, stability, and signaling pathways, as well as acting as key mediators between the virus and its host.
In this review, we focus on the multiple functions of DUBs in RIG-I-like receptors (RLRs) and stimulator of interferon genes (STING)-mediated antiviral signaling pathways, oncoviruses regulation of NF-κB activation, oncoviral life cycle, and the potential of DUB inhibitors as therapeutic strategies.
American Psychological Association (APA)
Li, Yueshuo& Shi, Feng& Hu, Jianmin& Xie, Longlong& Bode, Ann M.& Cao, Ya. 2019. The Role of Deubiquitinases in Oncovirus and Host Interactions. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184014
Modern Language Association (MLA)
Li, Yueshuo…[et al.]. The Role of Deubiquitinases in Oncovirus and Host Interactions. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1184014
American Medical Association (AMA)
Li, Yueshuo& Shi, Feng& Hu, Jianmin& Xie, Longlong& Bode, Ann M.& Cao, Ya. The Role of Deubiquitinases in Oncovirus and Host Interactions. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184014