Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model
Joint Authors
Chen, Bi-Cheng
Zhu, Hong
Wang, Hongwei
Chen, Xuehai
Luo, Jiao
Wu, Minmin
Pan, Zhuo
Xie, Yue
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is a serious microvascular complication of diabetes.
Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy.
PTX3 is the only long pentraxin that can be detected in renal tissue.
In this study, we investigated the expression of PTX3 when early DN was reversed after islet transplantation.
Methods.
Diabetes was induced in rats by injecting streptozotocin (STZ).
Twelve weeks later, the diabetic rats were divided into 2 groups: the islet transplantation group (IT) and the diabetic nephropathy group (DN).
Renal injury, renal function, and the expression of PTX3 in the plasma and the kidneys were assessed with urinalysis, immunohistochemical staining, and Western blot, respectively.
Results.
The expression of PTX3 in the kidney was significantly decreased in the DN group but increased in the IT group because of the reversal of DN.
Conclusions.
Our data showed that the level of PTX3 in renal tissue is closely related to renal injury in DN.
This may be used to quantify the extent of renal injury in DN, provide a potential early indicator of renal tubular injury in early DN patients, and assess DN clinical progression.
American Psychological Association (APA)
Chen, Xuehai& Luo, Jiao& Wu, Minmin& Pan, Zhuo& Xie, Yue& Wang, Hongwei…[et al.]. 2018. Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1184018
Modern Language Association (MLA)
Chen, Xuehai…[et al.]. Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model. Journal of Diabetes Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1184018
American Medical Association (AMA)
Chen, Xuehai& Luo, Jiao& Wu, Minmin& Pan, Zhuo& Xie, Yue& Wang, Hongwei…[et al.]. Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1184018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184018