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Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage
Joint Authors
Lv, Jiao
Chen, Miao-Miao
Mu, Zhi-Hao
Wang, Fang
Qian, Zhong-Yi
Zhou, Lei
Guo, Qiu-Ting
Zhao, Zhi-Min
Pan, Yu-Ping
Liao, Xin-Yu
Yang, Zhi-Hong
Cai, Ning
Li, Shu-De
Zou, Ying-Ying
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-09
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Diabetic retinopathy is the leading cause of blindness, yet its treatment is very limited.
Anti-VEGF drug has been widely applied in ocular disease, but its effects on diabetic retinopathy and the underlying mechanism have remained to be fully explored.
To elucidate the role of anti-VEGF treatment, we sought to determine the effects of bevacizumab on diabetic neurovascular changes extending from the 3rd to 9th week with induced diabetes in adult rats.
The retinal neurovascular changes included increased expression of VEGF, nNOS, iNOS, eNOS, and NO in the course of diabetes progression.
In diabetic rats given bevacizumab injection, the ganglion cell loss and alterations of retinal thickness were ameliorated.
In this connection, the immunofluorescence labeling of the above biomarkers was noticeably decreased.
Along with this, Western blotting confirmed that bevacizumab treatment was associated with a decrease of VEGF, Flk-1, and cAMP response element binding and protein kinase C protein expression.
The present results suggest that bevacizumab treatment in the early stage of the retinopathy may ameliorate the lesions of retinopathy, in which VEGF/Flk-1 signaling has been shown here to play an important role.
American Psychological Association (APA)
Lv, Jiao& Chen, Miao-Miao& Mu, Zhi-Hao& Wang, Fang& Qian, Zhong-Yi& Zhou, Lei…[et al.]. 2018. Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1184039
Modern Language Association (MLA)
Lv, Jiao…[et al.]. Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage. Journal of Diabetes Research No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1184039
American Medical Association (AMA)
Lv, Jiao& Chen, Miao-Miao& Mu, Zhi-Hao& Wang, Fang& Qian, Zhong-Yi& Zhou, Lei…[et al.]. Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1184039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184039