Ultrasound-Induced Blood-Brain-Barrier Opening Enhances Anticancer Efficacy in the Treatment of Glioblastoma: Current Status and Future Prospects
Joint Authors
Yan, Fei
Deng, Zhiting
Sheng, Zonghai
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Glioblastoma multiforme (GBM) diffusely infiltrates normal brain tissue.
The presence of the blood-brain barrier (BBB) poses difficulties for targeted delivery of currently available antitumor drugs.
Novel brain drug delivery strategies are far from satisfactory for glioma treatment.
Recently, focused ultrasound (FUS) combined with microbubbles presents a transient, reversible, and noninvasive approach for local induction of BBB opening.
This strategy demonstrated its potential to increase local concentrations of both diagnostic and therapeutic agents in glioma therapy.
Current status and related physic mechanisms of this drug delivery technique are discussed in this review.
Delivery efficiency enhancement in many preclinical glioma models was obtained by FUS-BBB opening combined with various nanoparticles.
And, the clinical translational status of FUS-BBB will be discussed.
American Psychological Association (APA)
Deng, Zhiting& Sheng, Zonghai& Yan, Fei. 2019. Ultrasound-Induced Blood-Brain-Barrier Opening Enhances Anticancer Efficacy in the Treatment of Glioblastoma: Current Status and Future Prospects. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184042
Modern Language Association (MLA)
Deng, Zhiting…[et al.]. Ultrasound-Induced Blood-Brain-Barrier Opening Enhances Anticancer Efficacy in the Treatment of Glioblastoma: Current Status and Future Prospects. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1184042
American Medical Association (AMA)
Deng, Zhiting& Sheng, Zonghai& Yan, Fei. Ultrasound-Induced Blood-Brain-Barrier Opening Enhances Anticancer Efficacy in the Treatment of Glioblastoma: Current Status and Future Prospects. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184042