Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer

Joint Authors

Scavo, Maria Principia
Cigliano, Antonio
Depalo, Nicoletta
Fanizza, Elisabetta
Bianco, Maria Grazia
Denora, Nunzio
Laquintana, Valentino
Curri, Maria Lucia
Lorusso, Dionigi
Lotesoriere, Claudio
Panarese, Alba
Giannelli, Gianluigi

Source

Journal of Oncology

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-06-02

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases
Medicine

Abstract EN

Extracellular vesicles (EVs) are involved in intercellular communication during the carcinogenesis.

Our attention has been focused on small EVs (sEVs) protein content in colorectal and gastric cancer (CRC and GC).

Frizzled (FZD) proteins, a family of receptors comprised in the Wnt signaling pathway, play an important role in the carcinogenesis of CRC and GC.

Here, the expression of a specific FZD protein, namely, FZD-10, was investigated in the sEVs extracted from plasma of patients affected by CRC and GC as involved in canonical and noncanonical Wnt signaling in cancer stem cells with a subsequent modification of cellular heterogeneity, omics reprogramming, and tumor plasticity.

The expression of FZD-10 protein in the sEVs extracted from plasma of patients affected by CRC and GC and sEVs from plasma of healthy subjects was evaluated against the level of protein Hsp70, established as EVs specific markers along with CD63 and ALIX proteins.

The FZD-10 extract from sEVs isolated from plasma of the controls and the CRC or GC subjects indicated that its expression in oncological patients was higher than in the control group, while, at the end of the treatment, it reached values comparable with the average level of controls.

Furthermore, the level of FZD-10 in the whole plasma was found comparable with its level in the sEVs extract.

The level of FZD-10 in the sEVs represents a potential reliable biomarker with a valuable prognostic function for the diagnosis of CRC and GC and for monitoring the treatment response.

American Psychological Association (APA)

Scavo, Maria Principia& Cigliano, Antonio& Depalo, Nicoletta& Fanizza, Elisabetta& Bianco, Maria Grazia& Denora, Nunzio…[et al.]. 2019. Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184073

Modern Language Association (MLA)

Scavo, Maria Principia…[et al.]. Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer. Journal of Oncology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1184073

American Medical Association (AMA)

Scavo, Maria Principia& Cigliano, Antonio& Depalo, Nicoletta& Fanizza, Elisabetta& Bianco, Maria Grazia& Denora, Nunzio…[et al.]. Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184073

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1184073