Low Expression of GLIS2 Gene Might Associate with Radiosensitivity of Gastric Cancer
Joint Authors
Sun, Haitong
Gu, Jincheng
Li, Zhongyang
Liu, Qianqian
Lin, Jiaxi
Tian, Ye
Cao, Jianping
Qin, Hualong
Tang, Zaixiang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human gene GLIS family zinc finger 2 (GLIS2) is a member of GLI-similar zinc finger protein family.
Previous studies indicated GLIS2 gene involved in tumorigenesis mechanisms.
However, the association between GLIS2 expression and radiosensitivity of gastric cancer has not been well understood.
In this study, we used the gastric cancer database in TCGA, and significant association was observed between the low expression of GLIS2 and radiosensitivity of patients with gastric cancer.
The adjusted HR values for radiotherapy were 0.162(0.035-0.756) and 0.089(0.014-0.564), with p values 0.021 and 0.010, respectively, in training and testing data, for these patients with low expression of GLIS2, while for patients with high expression of GLIS2, there was no significant survival difference between radiotherapy and nonradiotherapy groups.
The adjusted HR were 0.676(0.288-1.586) and 0.508(0.178-1.450), with p values 0.368 and 0.206 in training and testing data, respectively.
Further study showed that, for low expression patients, radiotherapy did not significantly increase new tumor event rate and disease progression rate, which partially supported our assumption.
These results suggested that low expression of GLIS2 might significantly associate with the radiosensitivity of patients with gastric cancer.
The GLIS2 gene might be a potential effective molecular marker of gastric cancer for precise radiotherapy.
American Psychological Association (APA)
Sun, Haitong& Gu, Jincheng& Li, Zhongyang& Liu, Qianqian& Lin, Jiaxi& Tian, Ye…[et al.]. 2019. Low Expression of GLIS2 Gene Might Associate with Radiosensitivity of Gastric Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184084
Modern Language Association (MLA)
Sun, Haitong…[et al.]. Low Expression of GLIS2 Gene Might Associate with Radiosensitivity of Gastric Cancer. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184084
American Medical Association (AMA)
Sun, Haitong& Gu, Jincheng& Li, Zhongyang& Liu, Qianqian& Lin, Jiaxi& Tian, Ye…[et al.]. Low Expression of GLIS2 Gene Might Associate with Radiosensitivity of Gastric Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184084