Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma
Joint Authors
Kanayama, Tomohiro
Noguchi, Kei
Niwa, Ayumi
Miyai, Masafumi
Kawaguchi, Masaya
Ishida, Kazuhisa
Hatano, Yuichiro
Niwa, Masayuki
Tomita, Hiroyuki
Hara, Akira
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glioblastoma (GBM) is the most common and the most malignant primary brain tumor and is characterized by rapid proliferation, invasion into surrounding normal brain tissues, and consequent aberrant vascularization.
In these characteristics of GBM, invasive properties are responsible for its recurrence after various therapies.
The histomorphological patterns of glioma cell invasion have often been referred to as the “secondary structures of Scherer.” The “secondary structures of Scherer” can be classified mainly into four histological types as (i) perineuronal satellitosis, (ii) perivascular satellitosis, (iii) subpial spread, and (iv) invasion along the white matter tracts.
In order to develop therapeutic interventions to mitigate glioma cell migration, it is important to understand the biological mechanism underlying the formation of these secondary structures.
The main focus of this review is to examine new molecular pathways based on the histopathological evidence of GBM invasion as major prognostic factors for the high recurrence rate for GBMs.
The histopathology-based pharmacological and biological targets for treatment strategies may improve the management of invasive and resistant GBMs.
American Psychological Association (APA)
Hara, Akira& Kanayama, Tomohiro& Noguchi, Kei& Niwa, Ayumi& Miyai, Masafumi& Kawaguchi, Masaya…[et al.]. 2019. Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184090
Modern Language Association (MLA)
Hara, Akira…[et al.]. Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184090
American Medical Association (AMA)
Hara, Akira& Kanayama, Tomohiro& Noguchi, Kei& Niwa, Ayumi& Miyai, Masafumi& Kawaguchi, Masaya…[et al.]. Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184090