Heat Shock Proteins in Cancer Immunotherapy
Joint Authors
Das, Jugal Kishore
Xiong, Xiaofang
Ren, Xingcong
Yang, Jin-Ming
Song, Jianxun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Heat shock proteins (HSPs) are highly conserved molecular chaperones with divergent roles in various cellular processes.
The HSPs are classified according to their molecular size as HSP27, HSP40, HSP60, HSP70, and HSP90.
The HSPs prevent nonspecific cellular aggregation of proteins by maintaining their native folding energetics.
The disruption of this vital cellular process, driven by the aberrant expression of HSPs, is implicated in the progression of several different carcinomas.
Many HSPs are also actively involved in promoting the proliferation and differentiation of tumor cells, contributing to their metastatic phenotype.
Upregulation of these HSPs is associated with the poor outcome of anticancer therapy in clinical settings.
On the other hand, these highly expressed HSPs may be exploited as viable immunotherapeutic targets for different types of cancers.
This review discusses recent advances and perspectives on the research of HSP-based cancer immunotherapy.
American Psychological Association (APA)
Das, Jugal Kishore& Xiong, Xiaofang& Ren, Xingcong& Yang, Jin-Ming& Song, Jianxun. 2019. Heat Shock Proteins in Cancer Immunotherapy. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184114
Modern Language Association (MLA)
Das, Jugal Kishore…[et al.]. Heat Shock Proteins in Cancer Immunotherapy. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1184114
American Medical Association (AMA)
Das, Jugal Kishore& Xiong, Xiaofang& Ren, Xingcong& Yang, Jin-Ming& Song, Jianxun. Heat Shock Proteins in Cancer Immunotherapy. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184114