From Whole-Brain Radiotherapy to Immunotherapy: A Multidisciplinary Approach for Patients with Brain Metastases from NSCLC
Joint Authors
Papadimitriou, Christos A.
Zygogianni, Anna
Protopapa, Maria
Nikoloudi, Styliani
Gogalis, Giannis
Kouloulias, Vassilis
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Non-small cell lung cancer patients with brain metastases have a multitude of treatment options, but there is currently no international and multidisciplinary consensus concerning their optimal treatment.
Local therapies have the principal role, especially in symptomatic patients.
Advances in surgery and radiation therapy manage considerable local control.
Systemic treatments have shown effect in clinical trials and in real life clinical settings; yet, at present, this is restricted to patients with asymptomatic or stable intracranial lesions.
Targeted agents can have a benefit only in patients with EGFR mutations or ALK rearrangement.
Immunotherapy has shown impressive results in patients with PD-L1 expression in tumor cells.
Its effects can be further enhanced by a synergy with radiotherapy, possibly by increasing the percentage of responders.
The present review summarizes the need for more effective systemic treatments, so that the increased intracranial control achieved by local treatments can be translated in an increase in overall survival.
American Psychological Association (APA)
Protopapa, Maria& Kouloulias, Vassilis& Nikoloudi, Styliani& Papadimitriou, Christos A.& Gogalis, Giannis& Zygogianni, Anna. 2019. From Whole-Brain Radiotherapy to Immunotherapy: A Multidisciplinary Approach for Patients with Brain Metastases from NSCLC. Journal of Oncology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184118
Modern Language Association (MLA)
Protopapa, Maria…[et al.]. From Whole-Brain Radiotherapy to Immunotherapy: A Multidisciplinary Approach for Patients with Brain Metastases from NSCLC. Journal of Oncology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1184118
American Medical Association (AMA)
Protopapa, Maria& Kouloulias, Vassilis& Nikoloudi, Styliani& Papadimitriou, Christos A.& Gogalis, Giannis& Zygogianni, Anna. From Whole-Brain Radiotherapy to Immunotherapy: A Multidisciplinary Approach for Patients with Brain Metastases from NSCLC. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184118