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Altered CSF Proteomic Profiling of Paediatric Acute Lymphocytic Leukemia Patients with CNS Infiltration
Joint Authors
Ma, Xuelei
Zhou, Ruofan
Mo, Fei
Liu, Xiaobei
Zhao, Yunuo
Zhou, Hui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
For childhood acute lymphocytic leukemia (ALL), central nervous system leukemia (CNSL) is still the main reason of treatment failure.
Changes of cerebrospinal fluid (CSF) proteome are deemed to occur after intrathecal chemotherapy.
Objective.
To find critical CSF biomarkers, which could be utilized to increase diagnostic and prognostic accuracy of CNSL.
Methods.
We performed proteomic profiling of CSF before and after the treatment of six sporadic paediatric patients diagnosed as ALL with central nervous system (CNS) involvement.
CSF samples were properly processed and analyzed through the use of label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Results.
Among identified 428 unique proteins in all CSF samples, we quantified 10 altered proteins with diverse biological functions after induction chemotherapy.
Conclusions.
The levels of those 10 proteins change during the treatment of CNSL.
Some of the proteins are likely to play a vital biological role as biomarkers for the development of ALL.
In addition, our results indicated the feasible and reproducible utility of CSF for diagnosis and prognosis of patients with CNSL.
American Psychological Association (APA)
Mo, Fei& Ma, Xuelei& Liu, Xiaobei& Zhou, Ruofan& Zhao, Yunuo& Zhou, Hui. 2019. Altered CSF Proteomic Profiling of Paediatric Acute Lymphocytic Leukemia Patients with CNS Infiltration. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184122
Modern Language Association (MLA)
Mo, Fei…[et al.]. Altered CSF Proteomic Profiling of Paediatric Acute Lymphocytic Leukemia Patients with CNS Infiltration. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1184122
American Medical Association (AMA)
Mo, Fei& Ma, Xuelei& Liu, Xiaobei& Zhou, Ruofan& Zhao, Yunuo& Zhou, Hui. Altered CSF Proteomic Profiling of Paediatric Acute Lymphocytic Leukemia Patients with CNS Infiltration. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184122