Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation
Joint Authors
Horiuchi, Masahisa
Kawaguchi, Hiroaki
Arimura, Emi
Pulong, Wijang Pralampita
Ushikai, Miharu
Abe, Masaharu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Different involvement of leptin signaling in food intake (FI) and body temperature (BT) in pups and adults has been suggested.
However, the leptin receptor (Lepr) long-form-deficient (db) mouse line has not been fully examined in pups.
In the most available db mouse line, wild-type (WT) mice have a mutation in the dedicator of cytokinesis 7 gene, named misty, which was recently revealed to be involved in neuronal development.
Therefore, we established a line of db mice without the misty mutation using natural mating.
Adult (8 weeks of age) homozygous db/db mice displayed significantly higher core body weight (BW) and FI and significantly lower core BT than WT mice.
However, postnatal (2 weeks of age) db/db mice displayed similar BW and milk intake and significantly lower core BT than WT mice.
Correspondingly, adult and postnatal db/db mice exhibited altered mRNA levels of hypothalamic orexigenic and anorexigenic peptide in adults but not in pups.
Additionally, db/db mice displayed significantly lower mRNA levels of brown adipose tissue uncoupling protein 1 at both ages.
In conclusion, the db mouse line without the misty mutation clearly showed the different involvements of the Lepr long form in FI and BT in pups and adults.
American Psychological Association (APA)
Pulong, Wijang Pralampita& Ushikai, Miharu& Arimura, Emi& Abe, Masaharu& Kawaguchi, Hiroaki& Horiuchi, Masahisa. 2018. Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1184129
Modern Language Association (MLA)
Pulong, Wijang Pralampita…[et al.]. Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1184129
American Medical Association (AMA)
Pulong, Wijang Pralampita& Ushikai, Miharu& Arimura, Emi& Abe, Masaharu& Kawaguchi, Hiroaki& Horiuchi, Masahisa. Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1184129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184129