Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice
Joint Authors
Gu, Jianqiu
Cong, Huiying
Zhong, Wenxia
Wang, Yiying
Fan, Bin
Ikuyama, Shoichiro
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity.
Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles.
However, the effect of PYC on obesity has never been explored.
In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E- (ApoE-) deficient mice.
The results showed that PYC treatment clearly reversed body weight and the mass of eWAT gain resulting from a high-cholesterol and high-fat diet (HCD), but no difference in food intake.
The morphology results showed that the size of the adipocytes in the PYC-treated mice was obviously smaller than that in the HCD-fed mice.
Next, we found that PYC upregulated the expression of genes related to lipolysis (ATGL and HSL), while it decreased the mRNA level of PLIN1.
PYC significantly increased the expression of UCP1 and other genes related to beige adipogenesis.
Additionally, PYC increased the expression of proteins related to the protein kinase A (PKA) signaling pathway.
The findings suggested that PYC decreased obesity by promoting lipolysis and WAT browning.
Thus, PYC may be a novel therapeutic target for obesity.
American Psychological Association (APA)
Cong, Huiying& Zhong, Wenxia& Wang, Yiying& Ikuyama, Shoichiro& Fan, Bin& Gu, Jianqiu. 2018. Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1184138
Modern Language Association (MLA)
Cong, Huiying…[et al.]. Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1184138
American Medical Association (AMA)
Cong, Huiying& Zhong, Wenxia& Wang, Yiying& Ikuyama, Shoichiro& Fan, Bin& Gu, Jianqiu. Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1184138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184138