Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children
Joint Authors
Zhu, Jinhong
He, Jing
Xia, Huimin
Jia, Wei
Fu, Wen
Zhu, Shibo
Deng, Fuming
Liu, Guo-Chang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Wilms’ tumor is renal tumor of childhood, characterized by the appearance of embryonic renal tissue and other kidney malformations.
The genetic etiology of sporadic Wilms’ tumor remains largely unknown.
Neurofilament light (NEFL) is a tumor suppressor.
We evaluated the association between three NEFL gene polymorphisms (rs11994014 G>A, rs2979704 T>C and rs1059111 A>T) and Wilms’ tumor susceptibility in a Chinese population consisting of 145 cases and 531 controls.
In the single locus analysis, rs2979704 CC variant genotype was associated with a decreased risk of Wilms’ tumor [CC vs.
TT: adjusted odds ratio (OR)=0.48, 95% confidence interval (CI)=0.24-0.94; CC vs.
TT+CT: adjusted OR=0.51, 95% CI=0.27-0.97].
We also observed that carriers of the three protective genotypes had significantly decreased risk of Wilms’ tumor when compared to those with 0-2 protective genotypes (adjusted OR=0.49, 95% CI=0.25-0.95).
The association between rs11994014 G>A or rs1059111 A>T polymorphisms and Wilms’ tumor susceptibility did not reach statistical significance.
No significant association was detected in the stratified analyses.
Our findings suggested that the NEFL rs2979704 T>C polymorphism may be associated with Wilms’ tumor susceptibility in the Chinese population.
American Psychological Association (APA)
Jia, Wei& Zhu, Jinhong& Fu, Wen& Zhu, Shibo& Deng, Fuming& Xia, Huimin…[et al.]. 2019. Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children. Journal of Oncology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184146
Modern Language Association (MLA)
Jia, Wei…[et al.]. Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children. Journal of Oncology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1184146
American Medical Association (AMA)
Jia, Wei& Zhu, Jinhong& Fu, Wen& Zhu, Shibo& Deng, Fuming& Xia, Huimin…[et al.]. Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184146