Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children

Joint Authors

Zhu, Jinhong
He, Jing
Xia, Huimin
Jia, Wei
Fu, Wen
Zhu, Shibo
Deng, Fuming
Liu, Guo-Chang

Source

Journal of Oncology

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-04-01

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

Wilms’ tumor is renal tumor of childhood, characterized by the appearance of embryonic renal tissue and other kidney malformations.

The genetic etiology of sporadic Wilms’ tumor remains largely unknown.

Neurofilament light (NEFL) is a tumor suppressor.

We evaluated the association between three NEFL gene polymorphisms (rs11994014 G>A, rs2979704 T>C and rs1059111 A>T) and Wilms’ tumor susceptibility in a Chinese population consisting of 145 cases and 531 controls.

In the single locus analysis, rs2979704 CC variant genotype was associated with a decreased risk of Wilms’ tumor [CC vs.

TT: adjusted odds ratio (OR)=0.48, 95% confidence interval (CI)=0.24-0.94; CC vs.

TT+CT: adjusted OR=0.51, 95% CI=0.27-0.97].

We also observed that carriers of the three protective genotypes had significantly decreased risk of Wilms’ tumor when compared to those with 0-2 protective genotypes (adjusted OR=0.49, 95% CI=0.25-0.95).

The association between rs11994014 G>A or rs1059111 A>T polymorphisms and Wilms’ tumor susceptibility did not reach statistical significance.

No significant association was detected in the stratified analyses.

Our findings suggested that the NEFL rs2979704 T>C polymorphism may be associated with Wilms’ tumor susceptibility in the Chinese population.

American Psychological Association (APA)

Jia, Wei& Zhu, Jinhong& Fu, Wen& Zhu, Shibo& Deng, Fuming& Xia, Huimin…[et al.]. 2019. Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children. Journal of Oncology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184146

Modern Language Association (MLA)

Jia, Wei…[et al.]. Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children. Journal of Oncology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1184146

American Medical Association (AMA)

Jia, Wei& Zhu, Jinhong& Fu, Wen& Zhu, Shibo& Deng, Fuming& Xia, Huimin…[et al.]. Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184146

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1184146