In Vivo 3T Magnetic Resonance Imaging Using a Biologically Specific Contrast Agent for Prostate Cancer: A Nude Mouse Model
Joint Authors
Zehbe, Ingeborg
Curiel, L.
Abraham, Christopher Brian
Jani, Prashant
Turuba, Roxanne
Campbell, Michael
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We characterized in vivo a functional superparamagnetic iron-oxide magnetic resonance contrast agent that shortens the T2 relaxation time in magnetic resonance imaging (MRI) of prostate cancer xenografts.
The agent was developed by conjugating Molday ION™ carboxyl-6 (MIC6), with a deimmunized mouse monoclonal antibody (muJ591) targeting prostate-specific membrane antigen (PSMA).
This functional contrast agent could be used as a noninvasive method to detect prostate cancer cells that are PSMA positive and more readily differentiate them from surrounding tissues for treatment.
The functional contrast agent was injected intravenously into mice and its effect was compared to both MIC6 (without conjugated antibody) and phosphate-buffered saline (PBS) injection controls.
MR imaging was performed on a clinical 3T MRI scanner using a multiecho spin echo (MESE) sequence to obtain T2 relaxation time values.
Inductively coupled plasma atomic emission spectroscopy was used to confirm an increase in elemental iron in injected mice tumours relative to controls.
Histological examination of H&E stained tissues showed normal morphology of the tissues collected.
American Psychological Association (APA)
Abraham, Christopher Brian& Jani, Prashant& Turuba, Roxanne& Campbell, Michael& Zehbe, Ingeborg& Curiel, L.. 2017. In Vivo 3T Magnetic Resonance Imaging Using a Biologically Specific Contrast Agent for Prostate Cancer: A Nude Mouse Model. Journal of Nanotechnology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1184157
Modern Language Association (MLA)
Abraham, Christopher Brian…[et al.]. In Vivo 3T Magnetic Resonance Imaging Using a Biologically Specific Contrast Agent for Prostate Cancer: A Nude Mouse Model. Journal of Nanotechnology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1184157
American Medical Association (AMA)
Abraham, Christopher Brian& Jani, Prashant& Turuba, Roxanne& Campbell, Michael& Zehbe, Ingeborg& Curiel, L.. In Vivo 3T Magnetic Resonance Imaging Using a Biologically Specific Contrast Agent for Prostate Cancer: A Nude Mouse Model. Journal of Nanotechnology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1184157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184157