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The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components
Joint Authors
Chen, Ying-Tai
Ren, Hu
Shi, Su-Sheng
Wang, Nian-Chang
Wang, Xing
Zhao, Dong-Bing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Gastric adenocarcinoma patients with a neuroendocrine (NE) component are frequently observed in routine practice.
Several previous studies have investigated the influence of a NE component on the survival of these patients; however, the results were inconsistent.
Methods.
We retrospectively investigated a consecutive series of 95 gastric adenocarcinoma patients with a NE component and 190 gastric adenocarcinoma patients without a NE component.
We adopted 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, and 90% as the cut-off proportions of the NE component, respectively, and analyzed the patients’ overall survival according to the proportion of the NE component.
Results.
The 1-, 3-, and 5-year actual survival rates of the patients with a NE component were 90.1%, 72.3%, and 67.2%, respectively, and for those without a NE component 94.2%, 79.3%, and 75.7%, respectively.
The multivariate analysis showed that the patients with NE components >70% (HR: 2.156; 95% CI: 1.011, 4.597; p=0.047) and >90% (HR: 2.476; 95% CI: 1.088, 5.634; p=0.031) had significantly worse survival than those without a NE component.
Only the diameter of tumors (>4.64 cm) (HR: 2.585; 95% CI: 1.112, 6.006; p=0.027) and pN3 (HR: 2.953; 95% CI: 1.051, 8.293; p=0.040) were independently associated with worse overall survival for gastric adenocarcinoma patients with a NE component (all p<0.05).
Conclusion.
Gastric adenocarcinoma patients with a NE component >70% and >90% have significantly worse survival than those without a NE component.
Only the diameter of tumors and the number of metastatic lymph nodes are independent prognostic factors for gastric adenocarcinoma patients with a NE component.
American Psychological Association (APA)
Ren, Hu& Shi, Su-Sheng& Wang, Nian-Chang& Wang, Xing& Chen, Ying-Tai& Zhao, Dong-Bing. 2019. The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components. Journal of Oncology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184158
Modern Language Association (MLA)
Ren, Hu…[et al.]. The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components. Journal of Oncology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1184158
American Medical Association (AMA)
Ren, Hu& Shi, Su-Sheng& Wang, Nian-Chang& Wang, Xing& Chen, Ying-Tai& Zhao, Dong-Bing. The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184158