Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients
Joint Authors
Schatz, Jonathan H.
Byrnes, Diana M.
Vargas, Fernando
Dermarkarian, Christopher
Kahn, Ryan
Kwon, Deukwoo
Hurley, Judith
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acute lymphoblastic leukemia and other aggressive lymphoid malignancies like Burkitt leukemia/lymphoma have high incidence of central nervous system (CNS) involvement.
Various solid tumors, most notably breast cancer, can also metastasize into the CNS as a late stage complication causing devastating effects.
Intrathecal (IT) chemotherapy consisting of methotrexate, cytarabine, or the two in combination is frequently used for the prophylaxis and treatment of CNS metastasis.
Because of the high toxicity of these chemotherapeutic agents, however, their side effect profiles are potentially catastrophic.
The incidence of neurotoxicity secondary to IT chemotherapy is well defined in the pediatric literature but is poorly reported in adults.
Here, we investigated the incidence of neurologic and nonneurologic side effects secondary to IT chemotherapy in 109 consecutive adult patients over a two-year time period at hospitals associated with our institution.
Of 355 IT chemotherapy treatments received by these patients, 11 (3.10%) resulted in paresthesias or paralysis, which we defined as significant neurologic events in our analysis.
We also examined minor events that arose after IT chemotherapy, including back pain, headache, fever, vomiting, and asthenia.
At least one of these occurred after 30.70% of IT chemotherapy doses.
Clinicians involved in the care of patients receiving IT chemotherapy should be aware of these findings and consider treatment options lower rate of neurotoxicity such as high-dose systemic methotrexate.
American Psychological Association (APA)
Byrnes, Diana M.& Vargas, Fernando& Dermarkarian, Christopher& Kahn, Ryan& Kwon, Deukwoo& Hurley, Judith…[et al.]. 2019. Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients. Journal of Oncology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184182
Modern Language Association (MLA)
Byrnes, Diana M.…[et al.]. Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients. Journal of Oncology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1184182
American Medical Association (AMA)
Byrnes, Diana M.& Vargas, Fernando& Dermarkarian, Christopher& Kahn, Ryan& Kwon, Deukwoo& Hurley, Judith…[et al.]. Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184182