The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma
Joint Authors
Harb, Ola A.
Haggag, Rasha
Ali, Maged M.
El Shorbagy, Shereen
Abdelbary, Abeer M.
Abdelaziz, Lobna A.
Salim, Reham A.
Abdel Wahab, Khaled M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC).
Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator.
P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member which can mediate carcinogenesis through intracellular signaling.
Methods.
To assess their prognostic role; NEDD9 and p38 protein were evaluated in sections from 50 paraffin blocks of TCC.
Results.
The high expressions of NEDD9 and p38 protein were significantly associated with grade, stage, distant metastasis (p<0.001), number of tumors, lymph node metastasis, and tumor size (p<0.001, 0.002; 0.018, <0.001; and 0.004, 0.007, respectively).
High NEDD9 and p38 detection had a worse 3-year OS (p=0.041 and <0.001, respectively).
By multivariate analysis the NEDD9 and p38 protein expression levels and various clinicopathological criteria including gender, grade, stage of the tumor, and regional lymph node involvement were independent prognostic parameters of TCC of the urinary bladder patients’ outcome.
Conclusion.
NEDD9 and p38 protein expressions were poor prognostic markers of TCC.
American Psychological Association (APA)
Harb, Ola A.& Haggag, Rasha& Ali, Maged M.& El Shorbagy, Shereen& Abdelbary, Abeer M.& Abdelaziz, Lobna A.…[et al.]. 2017. The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma. Journal of Oncology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1184193
Modern Language Association (MLA)
Harb, Ola A.…[et al.]. The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma. Journal of Oncology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1184193
American Medical Association (AMA)
Harb, Ola A.& Haggag, Rasha& Ali, Maged M.& El Shorbagy, Shereen& Abdelbary, Abeer M.& Abdelaziz, Lobna A.…[et al.]. The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma. Journal of Oncology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1184193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184193