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DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy
Joint Authors
McCabe, Nuala
Kennedy, Richard D.
Gilmore, Elaine
Parkes, Eileen E.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Historically the development of anticancer treatments has been focused on their effect on tumor cells alone.
However, newer treatments have shifted attention to targets on immune cells, resulting in dramatic responses.
The effect of DNA repair deficiency on the microenvironment remains an area of key interest.
Moreover, established therapies such as DNA damaging treatments such as chemotherapy and PARP inhibitors further modify the tumor microenvironment.
Here we describe DNA repair pathways in breast cancer and activation of innate immune pathways in DNA repair deficiency, in particular, the STING (STimulator of INterferon Genes) pathway.
Breast tumors with DNA repair deficiency are associated with upregulation of immune checkpoints including PD-L1 (Programmed Death Ligand-1) and may represent a target population for single agent or combination immunotherapy treatment.
American Psychological Association (APA)
Gilmore, Elaine& McCabe, Nuala& Kennedy, Richard D.& Parkes, Eileen E.. 2019. DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy. Journal of Oncology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184213
Modern Language Association (MLA)
Gilmore, Elaine…[et al.]. DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy. Journal of Oncology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1184213
American Medical Association (AMA)
Gilmore, Elaine& McCabe, Nuala& Kennedy, Richard D.& Parkes, Eileen E.. DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184213