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C-Reactive Protein to Prealbumin Ratio (CPR): A Novel Inflammatory-Nutritional Prognostic Factor for Predicting Cancer-Specific Survival (CSS) and Overall Survival (OS) in Patients with Resectable Esophageal Squamous Cell Carcinoma
Joint Authors
Feng, Ji-Feng
Yang, Xun
Wang, Liang
Jiang, You-Hua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The inflammation and nutrition play an important role in prognosis.
A novel index combined with inflammatory and nutritional biomarkers, named C-reactive protein (CRP) to prealbumin (PALB) ratio (CPR), was initially reported to predict the prognosis in resectable esophageal squamous cell carcinoma (ESCC).
Patients and Methods.
A retrospective study was conducted including 346 resectable ESCC patients.
The X-tile program was used to confirm the optimal cut-off value.
The Kaplan-Meier methods and Cox regression analyses were performed to analyze the cancer-specific survival (CSS) and overall survival (OS).
Results.
The optimum cut-off point was 0.03 for CPR.
Patients with a high level of CPR (> 0.03) were associated with poor CSS (12.0% vs.
43.0%, P<0.001) and OS (11.2% vs.
40.7%, P<0.001).
Multivariate analyses revealed that CPR was an independent predictor in resectable ESCC patients (CSS, P=0.008; OS, P=0.007).
Conclusion.
This study, to the best of our knowledge, is the first to investigate prognostic role of CPR in patients with ESCC.
Our retrospective observations indicate that CPR, with the optimal cut-off value of 0.03, is a useful potential predictor in resectable ESCC patients.
American Psychological Association (APA)
Feng, Ji-Feng& Wang, Liang& Jiang, You-Hua& Yang, Xun. 2019. C-Reactive Protein to Prealbumin Ratio (CPR): A Novel Inflammatory-Nutritional Prognostic Factor for Predicting Cancer-Specific Survival (CSS) and Overall Survival (OS) in Patients with Resectable Esophageal Squamous Cell Carcinoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184217
Modern Language Association (MLA)
Feng, Ji-Feng…[et al.]. C-Reactive Protein to Prealbumin Ratio (CPR): A Novel Inflammatory-Nutritional Prognostic Factor for Predicting Cancer-Specific Survival (CSS) and Overall Survival (OS) in Patients with Resectable Esophageal Squamous Cell Carcinoma. Journal of Oncology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1184217
American Medical Association (AMA)
Feng, Ji-Feng& Wang, Liang& Jiang, You-Hua& Yang, Xun. C-Reactive Protein to Prealbumin Ratio (CPR): A Novel Inflammatory-Nutritional Prognostic Factor for Predicting Cancer-Specific Survival (CSS) and Overall Survival (OS) in Patients with Resectable Esophageal Squamous Cell Carcinoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184217