Cancer Stem Cells: From Historical Roots to a New Perspective
Author
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The relationships between cancer and stemness have a long history that is traced here.
From the mid-19th century when the first theory on the embryonic origin of cancer was formulated to works on embryonal carcinoma cells in the mid-20th century, many steps have been crossed leading to the current cancer stem cell theory postulating that tumor growth is supported by a small fraction of the tumoral cells that have stem-like properties.
However, in the last fifteen years, many works regularly encourage us to revise the concept of cancer stem cell.
This article mentions key results that lead to a new perspective where cancer stem cells are primarily seen as cells exhibiting increased epigenetic plasticity and increased gene expression variability.
This perspective suggests new therapeutical interventions consisting in stabilizing gene expression to control cancer cell proliferation and prevent stochastic gene expression variations that could lead to therapeutic resistance.
American Psychological Association (APA)
Capp, Jean-Pascal. 2019. Cancer Stem Cells: From Historical Roots to a New Perspective. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184274
Modern Language Association (MLA)
Capp, Jean-Pascal. Cancer Stem Cells: From Historical Roots to a New Perspective. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184274
American Medical Association (AMA)
Capp, Jean-Pascal. Cancer Stem Cells: From Historical Roots to a New Perspective. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184274