Associations of Diabetes and Obesity with Risk of Abdominal Aortic Aneurysm in Men
Joint Authors
Gaziano, J. Michael
Song, Yiqing
Wang, Lu
Djousse, Luc
Akinkuolie, Akintunde O.
Matsumoto, Chisa
Manson, JoAnn E.
Sesso, Howard D.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The associations of diabetes and obesity with the risk of abdominal aortic aneurysm (AAA) are inconclusive in previous studies.
Subjects/Methods.
We conducted prospective analysis in the Physicians’ Health Study.
Among 25,554 male physicians aged ≥ 50 years who reported no AAA at baseline, 471 reported a newly diagnosed AAA during a mean of 10.4 years’ follow-up.
Results.
Compared with men who had baseline body mass index (BMI) < 25 kg/m2, the multivariable hazard ratio (HR [95% CI]) of newly diagnosed AAA was 1.30 [1.06–1.59] for BMI 25–<30 kg/m2 and 1.69 [1.24–2.30] for BMI ≥ 30 kg/m2.
The risk of diagnosed AAA was significantly higher by 6% with each unit increase in baseline BMI.
This association was consistent regardless of the other known AAA risk factors and preexisting vascular diseases.
Overall, baseline history of diabetes tended to be associated with a lower risk of diagnosed AAA (HR = 0.79 [0.57–1.11]); this association appeared to vary by follow-up time (HR = 1.56 and 0.63 during ≤ and >2 years’ follow-up, resp.).
Conclusion.
In a large cohort of middle-aged and older men, obesity was associated with a higher risk, while history of diabetes tended to associate with a lower risk of diagnosed AAA, particularly over longer follow-up.
American Psychological Association (APA)
Wang, Lu& Djousse, Luc& Song, Yiqing& Akinkuolie, Akintunde O.& Matsumoto, Chisa& Manson, JoAnn E.…[et al.]. 2017. Associations of Diabetes and Obesity with Risk of Abdominal Aortic Aneurysm in Men. Journal of Obesity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1184279
Modern Language Association (MLA)
Wang, Lu…[et al.]. Associations of Diabetes and Obesity with Risk of Abdominal Aortic Aneurysm in Men. Journal of Obesity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1184279
American Medical Association (AMA)
Wang, Lu& Djousse, Luc& Song, Yiqing& Akinkuolie, Akintunde O.& Matsumoto, Chisa& Manson, JoAnn E.…[et al.]. Associations of Diabetes and Obesity with Risk of Abdominal Aortic Aneurysm in Men. Journal of Obesity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1184279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184279