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Long-Term Survival, Quality of Life, and Psychosocial Outcomes in Advanced Melanoma Patients Treated with Immune Checkpoint Inhibitors
Joint Authors
Neyns, Bart
Rogiers, Anne
Boekhout, Annelies
Schwarze, Julia K.
Awada, Gil
Blank, Christian U.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Immune checkpoint inhibitors have become a standard of care option for the treatment of patients with advanced melanoma.
Since the approval of the first immune checkpoint (CTLA-4) inhibitor ipilimumab in 2011 and programmed death-1 (PD-1) blocking monoclonal antibodies pembrolizumab and nivolumab thereafter, an increasing proportion of patients with unresectable advanced melanoma achieved long-term overall survival.
Little is known about the psychosocial wellbeing, neurocognitive function, and quality of life (QOL) of these survivors.
Knowledge about the long term side-effects of these novel treatments is scarce as long-term survivorship is a novel issue in the field of immunotherapy.
The purpose of this review is to summarize our current knowledge regarding the survival and safety results of pivotal clinical trials in the field of advanced melanoma and to highlight potential long-term consequences that are likely to impact psychosocial wellbeing, neurocognitive functioning, and QOL.
The issues raised substantiate the need for clinical investigation of these issues with the aim of optimizing comprehensive health care for advanced melanoma survivors.
American Psychological Association (APA)
Rogiers, Anne& Boekhout, Annelies& Schwarze, Julia K.& Awada, Gil& Blank, Christian U.& Neyns, Bart. 2019. Long-Term Survival, Quality of Life, and Psychosocial Outcomes in Advanced Melanoma Patients Treated with Immune Checkpoint Inhibitors. Journal of Oncology،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1184287
Modern Language Association (MLA)
Rogiers, Anne…[et al.]. Long-Term Survival, Quality of Life, and Psychosocial Outcomes in Advanced Melanoma Patients Treated with Immune Checkpoint Inhibitors. Journal of Oncology No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1184287
American Medical Association (AMA)
Rogiers, Anne& Boekhout, Annelies& Schwarze, Julia K.& Awada, Gil& Blank, Christian U.& Neyns, Bart. Long-Term Survival, Quality of Life, and Psychosocial Outcomes in Advanced Melanoma Patients Treated with Immune Checkpoint Inhibitors. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1184287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184287