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Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience
Joint Authors
Esin, Ece
Simsek, Cem
Yalcin, Suayib
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-31, 31 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-20
Country of Publication
Egypt
No. of Pages
31
Main Subjects
Abstract EN
Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades.
To date, the principle mechanisms of its action include impeding tumoral angiogenesis and modulation of hosts’ immune system, affecting directly tumor cells, their progenitors, and neighboring stromal cells.
Its better toxicity profile, lower cost, and easier use are main advantages over conventional therapies.
The evidence of metronomic chemotherapy for personalized medicine is growing, starting with unfit elderly patients and also for palliative treatment.
The literature reviewed in this article mainly demonstrates that metronomic chemotherapy is advantageous for selected patients and for certain types of malignancies, which make it a promising therapeutic approach for filling in the gaps.
More clinical studies are needed to establish a solidified role for metronomic chemotherapy with other treatment models in modern cancer management.
American Psychological Association (APA)
Simsek, Cem& Esin, Ece& Yalcin, Suayib. 2019. Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience. Journal of Oncology،Vol. 2019, no. 2019, pp.1-31.
https://search.emarefa.net/detail/BIM-1184319
Modern Language Association (MLA)
Simsek, Cem…[et al.]. Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience. Journal of Oncology No. 2019 (2019), pp.1-31.
https://search.emarefa.net/detail/BIM-1184319
American Medical Association (AMA)
Simsek, Cem& Esin, Ece& Yalcin, Suayib. Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-31.
https://search.emarefa.net/detail/BIM-1184319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184319