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The Four Horsemen in Colon Cancer
Joint Authors
Hernández-Luna, Marco Antonio
López-Briones, Sergio
Luria-Pérez, Rosendo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Worldwide, neoplasms of the gastrointestinal tract have a very high incidence and mortality.
Among these, colorectal cancer, which includes colon and rectum malignancies, representing both highest incidence and mortality.
While gallbladder cancer, another neoplasm associated to gastrointestinal tract occurs less frequently.
Genetic factors, inflammation and nutrition are important risk factors associated with colorectal cancer development.
Likewise, pathogenic microorganisms inducing intestinal dysbiosis have become an important scope to determine the role of bacterial infection on tumorigenesis.
Interestingly, in human biopsies of different types of gastrointestinal tract cancer, the presence of different bacterial strains, such as Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis and Salmonella enterica have been detected, and it has been considered as a high-risk factor to cancer development.
Therefore, pathogens infection could contribute to neoplastic development through different mechanisms; including intestinal dysbiosis, inflammation, evasion of tumoral immune response and activation of pro-tumoral signaling pathways, such as β catenin.
Here, we have reviewed the suggested bacterial molecular mechanisms and their possible role on development and progression of gastrointestinal neoplasms, focusing mainly on colon neoplasms, where the bacteria Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis and Salmonella enterica infect.
American Psychological Association (APA)
Hernández-Luna, Marco Antonio& López-Briones, Sergio& Luria-Pérez, Rosendo. 2019. The Four Horsemen in Colon Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184323
Modern Language Association (MLA)
Hernández-Luna, Marco Antonio…[et al.]. The Four Horsemen in Colon Cancer. Journal of Oncology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1184323
American Medical Association (AMA)
Hernández-Luna, Marco Antonio& López-Briones, Sergio& Luria-Pérez, Rosendo. The Four Horsemen in Colon Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184323