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Interaction of CD200 Overexpression on Tumor Cells with CD200R1 Overexpression on Stromal Cells: An Escape from the Host Immune Response in Rectal Cancer Patients
Joint Authors
Yalcin, Arzu D.
Sun, Xiao-Feng
Meng, Wen-Jian
Adell, Gunnar
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
CD200 imparts an immunoregulatory signal through its receptor, CD200R1, leading to the suppression of tumor specific immunity.
The mechanism of CD200:CD200R1 signaling pathway is still uncertain.
Our aim was to investigate the expression and localization of CD200 and its receptor CD200R1 and their clinical significance in rectal cancer patients.
We examined the immunohistochemical expressions and localizations of CD200 and CD200R1 in 140 rectal cancer patients.
Among the patients, 79 underwent the preoperative radiotherapy and the others were untreated prior to the surgery.
In addition, 121 matched normal rectal mucosa samples were evaluated.
The results of immunohistochemical analysis showed a strikingly high level of CD200 in tumor cells (p=0.001) and CD200R1 expression in normal mucosal epithelium and stromal cells.
Importantly, CD200R1 was overexpressed in stromal cells of the metastatic cancer patients compared to patients without metastases (p=0.002).
More than that, 87% of metastatic patients had a phenotype of upregulated CD200 in tumor cells accompanied by overexpressed CD200R1 in stromal cells.
In addition, low levels of CD200 were correlated with improved overall survival in untreated patients.
We showed that tumor-stroma communication through CD200 and its receptor interaction is selected in patients with high risk of relapse.
High levels of these molecules support instigation of the far and local metastatic nest that provides solid ground for metastasis.
Our current data also disclose a mechanism by which CD200:CD200R1 affects tumor progression and may strengthen the feasibility of targeting CD200 or CD200R1 as anticancer strategy.
American Psychological Association (APA)
Yalcin, Arzu D.& Meng, Wen-Jian& Adell, Gunnar& Sun, Xiao-Feng. 2019. Interaction of CD200 Overexpression on Tumor Cells with CD200R1 Overexpression on Stromal Cells: An Escape from the Host Immune Response in Rectal Cancer Patients. Journal of Oncology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184330
Modern Language Association (MLA)
Yalcin, Arzu D.…[et al.]. Interaction of CD200 Overexpression on Tumor Cells with CD200R1 Overexpression on Stromal Cells: An Escape from the Host Immune Response in Rectal Cancer Patients. Journal of Oncology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1184330
American Medical Association (AMA)
Yalcin, Arzu D.& Meng, Wen-Jian& Adell, Gunnar& Sun, Xiao-Feng. Interaction of CD200 Overexpression on Tumor Cells with CD200R1 Overexpression on Stromal Cells: An Escape from the Host Immune Response in Rectal Cancer Patients. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184330