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Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity
Joint Authors
Gurzu, Simona
Jung, Ioan
Kovacs, Zsolt
Molnar, Calin
Sincu, Mihaela
Banias, Laura
Satala, Catalin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Plasmacytoid urothelial carcinoma is a rare and aggressive histologic variant of high-grade carcinoma of the urinary bladder.
Few than 250 cases have been reported in the urinary bladder till January 2019.
In this paper, a case series of unusual gastrointestinal carcinomas with plasmacytoid morphology was included.
Only one similar case of the stomach was previously published and no such cases were found in colon.
Methods.
We present the complex immunoprofile, using a panel of 39 biomarkers, of the largest group of primary gastrointestinal carcinomas with plasmacytoid morphology reported in literature (one from upper rectum and six from stomach).
Results.
All of the seven cases showed lymph node metastases and only one survived over 25 weeks after surgical excision.
The indicators of aggressivity were age (over 60), advanced stage (from IIIA to IV), E-cadherin negativity, and vimentin positivity.
The immunoprofile indicated unfavorable prognosis for mesenchymal-type carcinomas (negativity for E-cadherin and positivity for vimentin, with membrane to nuclear translocation or negativity of β-catenin).
The survivor showed an “epithelial-type adenocarcinoma with plasmacytoid dedifferentiation”, with membrane positivity for E-cadherin and β-catenin and vimentin negativity.
All of the cases expressed c-MET and were negative for HER-2.
Conclusions.
Primary carcinoma with plasmacytoid morphology is a dedifferentiated variant of adenocarcinoma or poorly cohesive carcinomas.
Vimentin positive dedifferentiated-poorly cohesive carcinomas should be considered as mesenchymal-type highly malignant carcinomas.
This rare histologic variant of gastrointestinal cancer might respond to anti-c-MET tyrosine kinases.
American Psychological Association (APA)
Kovacs, Zsolt& Gurzu, Simona& Molnar, Calin& Sincu, Mihaela& Banias, Laura& Satala, Catalin…[et al.]. 2019. Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity. Journal of Oncology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184343
Modern Language Association (MLA)
Kovacs, Zsolt…[et al.]. Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity. Journal of Oncology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1184343
American Medical Association (AMA)
Kovacs, Zsolt& Gurzu, Simona& Molnar, Calin& Sincu, Mihaela& Banias, Laura& Satala, Catalin…[et al.]. Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184343