Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas
Joint Authors
Ten Eyck, Patrick
Rajan, Anand
Choi, Allen B.
Ofori-Amanfo, Georgina K.
Espinosa-Cotton, Madelyn
Sperry, Steven M.
Simons, Andrean L.
Gibson-Corley, Katherine N.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Interleukin-1 alpha (IL-1α) is a pleiotropic cytokine involved in inflammation and immune response and is upregulated in many solid tumors including head and neck squamous cell carcinomas.
Although IL-1α expression is generally associated with poor prognosis, the implications of the subcellular localization of IL-1α expression in patient outcomes are poorly understood.
This study is aimed at investigating the prognostic value of nuclear and cytoplasmic immunohistochemical IL-1α expression in oral squamous cell carcinomas (OSCCs).
Tissue microarrays containing 146 OSCCs were analyzed for IL-1α and epidermal growth factor receptor (EGFR) expression by immunohistochemistry.
IL-1α and EGFR expression scores were correlated with clinicopathological parameters and survival outcomes.
IL-1α expression was observed in the nuclear and/or cytoplasmic compartments in 98% of evaluable tumors and 78% of tumors expressed IL-1α in both compartments.
There were no differences observed in overall survival or progression-free survival between high, moderate, or negative IL-1α nuclear/cytoplasmic expression scores.
When IL-1α nuclear/cytoplasmic expression scores were stratified by positive or negative EGFR expression, tumors with a combined EGFR-positive and high nuclear IL-1α expression profile were significantly more likely to possess perineural invasion and were significantly associated with a high risk of tumor recurrence and worse progression-free survival compared to all other EGFR and combined IL-1α/EGFR expression profiles.
Altogether, nuclear IL-1α expression may enhance the prognostic value of EGFR in OSCC and warrants further study as a prognostic biomarker for recurrence.
American Psychological Association (APA)
Rajan, Anand& Gibson-Corley, Katherine N.& Choi, Allen B.& Ofori-Amanfo, Georgina K.& Ten Eyck, Patrick& Espinosa-Cotton, Madelyn…[et al.]. 2019. Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas. Journal of Oncology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184347
Modern Language Association (MLA)
Rajan, Anand…[et al.]. Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas. Journal of Oncology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1184347
American Medical Association (AMA)
Rajan, Anand& Gibson-Corley, Katherine N.& Choi, Allen B.& Ofori-Amanfo, Georgina K.& Ten Eyck, Patrick& Espinosa-Cotton, Madelyn…[et al.]. Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184347