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mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance
Joint Authors
Woo, Yunseo
Lee, Hyo-Ji
Jung, Young Mee
Jung, Yu-Jin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Radiotherapy is widely used for the treatment of cancer patients, but tumor radioresistance presents serious therapy challenges.
Tumor radioresistance is closely related to high levels of mTOR signaling in tumor tissues.
Therefore, targeting the mTOR pathway might be a strategy to promote solid tumor sensitivity to ionizing radiation.
Radioresistance is associated with enhanced antioxidant mechanisms in cancer cells.
Therefore, examination of the relationship between mTOR signaling and antioxidant mechanism-linked radioresistance is required for effective radiotherapy.
In particular, the effect of mTOR signaling on antioxidant glutathione induction by the Keap1-NRF2-xCT pathway is described in this review.
This review is expected to assist in the identification of therapeutic adjuvants to increase the efficacy of radiotherapy.
American Psychological Association (APA)
Woo, Yunseo& Lee, Hyo-Ji& Jung, Young Mee& Jung, Yu-Jin. 2019. mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance. Journal of Oncology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184367
Modern Language Association (MLA)
Woo, Yunseo…[et al.]. mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance. Journal of Oncology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1184367
American Medical Association (AMA)
Woo, Yunseo& Lee, Hyo-Ji& Jung, Young Mee& Jung, Yu-Jin. mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184367